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Laboratory of Super-Resolution Fluorescence Microscopy
School of Life Sciences
Principal Investigator: Yongdeng Zhang 章永登, Ph.D.

  (* co-first author; # corresponding author)

2024

  1. Zhu, S., Bradfield, C.J., Maminska, A., Park, E.S., Kim, B.H., Kumar, P., Huang, S., Kim, M., Zhang, Y., Bewersdorf, J. & MacMicking, J.D. Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Science 383, eabm9903 (2024). Link

  2. Peng, X., Ren, H., Yang, L., Tong, S., Zhou, R., Long, H., Wu, Y., Wang, L., Wu, Y., Zhang, Y., Shen, J., Zhang, J., Qiu, G., Wang, J., Han, C., Zhang, Y., Zhou, M., Zhao, Y., Xu, T., Tang, C., Chen, Z., Liu, H. & Chen, L. Readily releasable beta cells with tight Ca(2+)-exocytosis coupling dictate biphasic glucose-stimulated insulin secretion. Nature Metabolism 6, 238-253 (2024). Link

2023

  1. Cui, Q., Bi, H., Lv, Z., Wu, Q., Hua, J., Gu, B., Huo, C., Tang, M., Chen, Y., Chen, C., Chen, S., Zhang, X., Wu, Z., Lao, Z., Sheng, N., Shen, C., Zhang, Y., Wu, Z.Y., Jin, Z., Yang, P., Liu, H., Li, J. & Bai, G. Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules. Cell (2023). Link

  2.     Guo, M., Zhao, K., Guo, L., Zhou, R., He, Q., Lu, K., Li, T., Liu, D., Chen, J., Tang, J., Fu, X., Zhou, J., Zheng, B., Mann, S.I., Zhang, Y., Huang, J., Yang, B., Zhou, T., Lei, Y. & Dang, B. Copper assisted sequence-specific chemical protein conjugation at a single backbone amide. Nature Communications 14 (2023).Link

  3. Bailey, M.L.P., Pratt, S.E., Hinrichsen, M., Zhang, Y., Bewersdorf, J., Regan, L.J. & Mochrie, S.G.J. Uncovering diffusive states of the yeast membrane protein, Pma1, and how labeling method can change diffusive behavior. The European Physical Journal E 46 (2023). Link

2022

  1. Chung, K. K. H., Zhang, Z., Kidd, P., Zhang, Y., Williams, N. D., Rollins, B., Yang, Y., Lin, C., Baddeley, D., & Bewersdorf, J.#. Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging. Nature Methods, 19(5), 554-559 (2022). Link

  2. Yang, S., Jiang, H., Bian, W., Xu, W., Guo, Y., Song, S., Zheng, J., Kuang, X., Wu, C., Ding, X., Guo, X., Xue, L., Yu, Z., Zhang, Y., Ryoo, H. D., Li, X.#, & Ma, X.# Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation. PNAS, 119(42),(2022).Link

  3. Zhu, M.*, Zhang, L.*, Jin, L., Chen, J., Zhang, Y., & Xu, Y. DNA-PAINT Imaging Accelerated by Machine Learning [Original Research]. Frontiers in Chemistry, 10.(2022). Link

2021​

  1. Wang, J.*, Allgeyer, E.S.*, Sirinakis, G., Zhang, Y., Hu, K., Lessard, M.D., Li, Y., Diekmann, R., Phillips, M.A., Dobbie, I.M.#, Ries, J.#, Booth, M.J.# & Bewersdorf, J.# Implementation of a 4Pi-SMS super-resolution microscope. Nature Protocols 16, 677-727 (2021). Link

2020

  1. Zhang, Y.*, Schroeder, L.K.*, Lessard, M.D., Kidd, P., Chung, J., Song, Y., Benedetti, L., Li, Y., Ries, J., Grimm, J.B., Lavis, L.D., De Camilli, P., Rothman, J.E., Baddeley, D. & Bewersdorf, J.# Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging. Nature Methods 17, 225-231 (2020). Link

  2. Wang, L.*, Liu, Z.*, Wang, L., Wu, Q., Li, X., Xie, D., Zhang, H., Zhang, Y., Gu, L., Xue, Y., Yue, T., Liu, G., Ji, W., Wei, H., Xu, T. & Bai, L.# Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors. Cellular and Molecular Immunology 17, 496-506 (2020). Link

  3. Li, Y., Buglakova, E., Zhang, Y., Thevathasan, J.V., Bewersdorf, J. & Ries, J.# Accurate 4Pi single-molecule localization using an experimental PSF model. Optics Letters 45, 3765-3768 (2020). Link

  4. Kilian, N.#, Zhang, Y., LaMonica, L., Hooker, G., Toomre, D., Mamoun, C.B.# & Ernst, A.M.# Palmitoylated Proteins in Plasmodium falciparum-Infected Erythrocytes: Investigation with Click Chemistry and Metabolic Labeling. Bioessays 42, e1900145 (2020). Link

2019

  1. Schroeder, L.K., Barentine, A.E.S., Merta, H., Schweighofer, S., Zhang, Y., Baddeley, D., Bewersdorf, J.# & Bahmanyar, S.# Dynamic nanoscale morphology of the ER surveyed by STED microscopy. Journal of Cell Biology 218, 83-96 (2019). Link

  2. Hwang, J.Y., Mannowetz, N., Zhang, Y., Everley, R.A., Gygi, S.P., Bewersdorf, J., Lishko, P.V. & Chung, J.J.# Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Cell 177, 1480-1494 e1419 (2019). Link

2018

  1. Xue, Y.*, Xing, J.*, Wan, Y.*, Lv, X., Fan, L., Zhang, Y., Song, K., Wang, L., Wang, X., Deng, X., Baluska, F., Christie, J.M. & Lin, J.# Arabidopsis Blue Light Receptor Phototropin 1 Undergoes Blue Light-Induced Activation in Membrane Microdomains. Molecular Plant 11, 846-859 (2018). Link

  2. Karanastasis, A.A., Zhang, Y., Kenath, G.S., Lessard, M.D., Bewersdorf, J. & Ullal, C.K.# 3D mapping of nanoscale crosslink heterogeneities in microgels. Mater Horiz 5, 1130-1136 (2018). Link

2017

  1. Zhang, Y.*, Lara-Tejero, M.*, Bewersdorf, J.# & Galan, J.E.# Visualization and characterization of individual type III protein secretion machines in live bacteria. PNAS 114, 6098-6103 (2017). Link

  2. Takakura, H.*, Zhang, Y.*, Erdmann, R.S.*, Thompson, A.D.*, Lin, Y., McNellis, B., Rivera-Molina, F., Uno, S.N., Kamiya, M., Urano, Y., Rothman, J.E., Bewersdorf, J., Schepartz, A.# & Toomre, D.# Long time-lapse nanoscopy with spontaneously blinking membrane probes. Nature Biotechnology 35, 773-780 (2017). Link

  3. Lv, X.*, Jing, Y.*, Xiao, J., Zhang, Y., Zhu, Y., Julian, R. & Lin, J.# Membrane microdomains and the cytoskeleton constrain AtHIR1 dynamics and facilitate the formation of an AtHIR1-associated immune complex. Plant Journal 90, 3-16 (2017). Link

2016

  1. Huang, F.*, Sirinakis, G.*, Allgeyer, E.S., Schroeder, L.K., Duim, W.C., Kromann, E.B., Phan, T., Rivera-Molina, F.E., Myers, J.R., Irnov, I., Lessard, M., Zhang, Y., Handel, M.A., Jacobs-Wagner, C., Lusk, C.P., Rothman, J.E., Toomre, D., Booth, M.J. & Bewersdorf, J.# Ultra-High Resolution 3D Imaging of Whole Cells. Cell 166, 1028-1040 (2016). Link

  2. Del Viso, F.*, Huang, F.*, Myers, J., Chalfant, M., Zhang, Y., Reza, N., Bewersdorf, J., Lusk, C.P.# & Khokha, M.K.# Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia. Developmental Cell 38, 478-492 (2016). Link

2015

  1. Yuan, T., Lu, J., Zhang, J., Zhang, Y.# & Chen, L.# Spatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by the cytoskeleton in endocrine cells. Biophysical Journal 108, 251-260 (2015). Link

  2. Yuan, T.*, Liu, L.*, Zhang, Y.*, Wei, L.*, Zhao, S., Zheng, X., Huang, X., Boulanger, J., Gueudry, C., Lu, J., Xie, L., Du, W., Zong, W., Yang, L., Salamero, J., Liu, Y.# & Chen, L.# Diacylglycerol Guides the Hopping of Clathrin-Coated Pits along Microtubules for Exo-Endocytosis Coupling. Developmental Cell 35, 120-130 (2015). Link

  3. Liu, B.*, Xue, Y.*, Zhao, W.*, Chen, Y., Fan, C., Gu, L., Zhang, Y., Zhang, X., Sun, L., Huang, X., Ding, W., Sun, F., Ji, W.# & Xu, T.# Three-dimensional super-resolution protein localization correlated with vitrified cellular context. Sci Rep 5, 13017 (2015). Link

  4. Lin, Y., Long, J.J., Huang, F., Duim, W.C., Kirschbaum, S., Zhang, Y., Schroeder, L.K., Rebane, A.A., Velasco, M.G., Virrueta, A., Moonan, D.W., Jiao, J., Hernandez, S.Y., Zhang, Y. & Bewersdorf, J.# Quantifying and optimizing single-molecule switching nanoscopy at high speeds. PLoS ONE 10, e0128135 (2015). Link

  5. Ji, C., Zhang, Y., Xu, P., Xu, T. & Lou, X.# Nanoscale Landscape of Phosphoinositides Revealed by Specific Pleckstrin Homology (PH) Domains Using Single-molecule Superresolution Imaging in the Plasma Membrane. Journal of Biological Chemistry 290, 26978-26993 (2015). Link

  6. Han, R., Wang, L., Xu, F., Zhang, Y., Zhang, M., Liu, Z., Ren, F.# & Zhang, F.# Drift correction for single-molecule imaging by molecular constraint field, a distance minimum metric. BMC Biophys 8, 1 (2015). Link

2014 & before

  1. Gu, L.*, Sheng, Y.*, Chen, Y.*, Chang, H., Zhang, Y., Lv, P., Ji, W.# & Xu, T.# High-density 3D single molecular analysis based on compressed sensing. Biophysical Journal 106, 2443-2449 (2014). Link

  2. Zhang, Y.D.*, Chang, H.*, Gu, L.S., Zhao, Y.H., Xu, T.# & Ji, W.# Super-resolution microscopy of live cells using single molecule localization. Chinese Science Bulletin 58, 4519-4527 (2013). Link

  3. Zhang, Y.*, Gu, L.*, Chang, H.*, Ji, W.*, Chen, Y., Zhang, M., Yang, L., Liu, B., Chen, L.# & Xu, T.# Ultrafast, accurate, and robust localization of anisotropic dipoles. Protein & Cell 4, 598-606 (2013). Link

  4. Han, M., Chang, H., Zhang, P., Chen, T., Zhao, Y., Zhang, Y., Liu, P., Xu, T.# & Xu, P.# C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process. Protein & Cell 4, 364-372 (2013). Link

  5. Zhang, M.*, Chang, H.*, Zhang, Y.*, Yu, J., Wu, L., Ji, W., Chen, J., Liu, B., Lu, J., Liu, Y., Zhang, J., Xu, P.# & Xu, T.# Rational design of true monomeric and bright photoactivatable fluorescent proteins. Nature Methods 9, 727-729 (2012). Link

  6. Feng, W.-J., Zhou, W., Zhang, Y.-D., Wu, Z.-X. & Xu, T.# UNC-10 Regulates The Docking Step of DCV Exocytosis in C. elegans. Progress in Biochemistry and Biophysics 39, 556-562 (2012). Link

  7. Feng, W.*, Liang, T.*, Yu, J.*, Zhou, W., Zhang, Y., Wu, Z. & Xu, T.# RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans. Sci China Life Sci 55, 228-235 (2012). Link

  8. Chang, H.*, Zhang, M.*, Ji, W.*, Chen, J., Zhang, Y., Liu, B., Lu, J., Zhang, J., Xu, P.# & Xu, T.# A unique series of reversibly switchable fluorescent proteins with beneficial properties for various applications. PNAS 109, 4455-4460 (2012). Link

  9. Zhang, Y.D., Chen, L.Y.# & Xu, T.# Application of Improved Wavelet Transform in Biological Particle Detection. Progress in Biochemistry and Biophysics 37, 1144-1150 (2010). Link

  10. Lin, X.G.*, Ming, M.*, Chen, M.R.*, Niu, W.P., Zhang, Y.D., Liu, B., Jiu, Y.M., Yu, J.W., Xu, T.# & Wu, Z.X.# UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons. Biochemical and Biophysical Research Communications 397, 526-531 (2010). Link

  11. Jiu, Y.-M.*, Yu, J.-W.*, Lin, X.-G.*, Zhang, Y.-D., Wang, Y., Zhang, R.-Y. & Wu, Z.-X.# DCVs Exocytosis is Damaged in The Dominant Allele of β-G Spectrin Mutant in C. elegans. Progress in Biochemistry and Biophysics 2009, 1589-1596 (2010). Link

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